A NANOS3 mutation linked to protein degradation causes premature ovarian insufficiency

Homozygous Inactivating Mutation in NANOS3 in Two Sisters with Primary Ovarian Insufficiency

Despite the increasing understanding of female reproduction, the molecular diagnosis of primary ovarian insufficiency (POI) is seldom obtained. The RNA-binding protein NANOS3 poses as an interesting candidate gene for POI since members of the Nanos family have an evolutionarily conserved function in germ cell development and maintenance by repressing apoptosis. We performed mutational analysis ...

Role of microRNAs in premature ovarian insufficiency

Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follicle-stimulating hormone (FSH) in women <40-year-old, primarily originating from iatrogenic factors, karyotypic abnormalities, and genetic factors. However, the etiology of POI remains unkno...

Pathogenesis and Causes of Premature Ovarian Failure:An Update

Premature Ovarian Failure: A Critical Condition in The Reproductive Potential with Various Genetic Causes

Adrenal insufficiency due to hemorrhage in a premature neonate:A case report

Neonatal adrenal hemorrhage is more common than previously suspected.in most cases the diagnosis is made by post-mortem autopsy.however massive hemorrhage is less common.the most important cause is  trauma during birth,other contributing factors are:macrosomia,diabetic mothers,breech presentation,congenital syphilis,anoxia,hemorrhagic disease, and prematurity.clinical manifestations of the dise...